Myeloperoxidase Chemiluminescent Immunoassay

☑️  Description

MPO is a white blood cell-derived inflammatory enzyme that measures disease activity from the luminal aspect of the arterial wall.

when the artery wall is damaged, or inflamed, MPO is released by invading macrophages where it accumulates. MPO mediates the vascular inflammation that propagates plaque formation and activates protease cascades that are linked to plaque vulnerability. White blood cell activation in the bloodstream, in response to luminal injury of the artery wall including fissures, erosions or a degrading collagen cap, leads to MPO release in the bloodstream. This combination of detrimental effects demonstrates that MPO is actively involved in the progression of atherosclerosis.

☑️  Clinical Significance

1）Elevated MPO levels predict the risk of heart disease in subgroups otherwise associated with low risk.

2）Elevated MPO levels independently predict the risk of future cardiovascular events in patients presenting with an acute coronary syndrome.

3）Individuals with elevated MPO levels are more than 2x as likely to experience cardiovascular mortality.

4）MPO enhances cardiovascular risk prediction when used independently or alongside standard biomarker testing such as hsCRP.

5）Free MPO in the blood is a specific marker of vascular inflammation and vulnerable plaque/erosions/fissures.